Mixing Risks: Can You Drink Dayquil & Alcohol?


Mixing Risks: Can You Drink Dayquil & Alcohol?

The concurrent intake of Dayquil and alcoholic beverages presents a potential health hazard. Dayquil, a common over-the-counter medication used to alleviate cold and flu symptoms, contains active ingredients that can interact negatively with alcohol. These ingredients typically include acetaminophen, dextromethorphan, and phenylephrine, each carrying specific risks when combined with alcohol.

Combining these substances can amplify the side effects of both. Alcohol can increase the sedative effects of Dayquil, leading to drowsiness, impaired coordination, and slowed reaction time. Furthermore, acetaminophen, a common pain reliever in Dayquil, poses a risk of liver damage, particularly when consumed with alcohol. The combination increases the strain on the liver, potentially leading to serious and even life-threatening consequences. Historically, the risks associated with mixing medications and alcohol have been underestimated, contributing to accidental overdoses and adverse health outcomes.

Understanding the specific risks associated with each ingredient in Dayquil, along with the potential for liver damage and increased sedation, is crucial for making informed decisions about medication use. It is imperative to consult with a healthcare professional or pharmacist to ascertain the safety of combining any medication with alcohol and to discuss alternative treatment options.

1. Liver Damage

The liver, a silent workhorse of the human body, toils relentlessly to filter toxins and maintain equilibrium. Acetaminophen, a common analgesic in Dayquil, is generally safe when used as directed. However, its metabolism produces a byproduct that, in excess, can overwhelm the liver’s defenses. Alcohol, another substance processed by the liver, adds to this burden. When combined, the simultaneous assault significantly increases the risk of hepatic injury. Imagine the liver as a factory operating at full capacity; introducing both Dayquil and alcohol is akin to demanding it process double the workload with the same resources, inevitably leading to a breakdown.

Consider a hypothetical scenario: a person battling the flu decides to take Dayquil to alleviate symptoms. Later that evening, seeking relaxation, they consume alcoholic beverages. Unbeknownst to them, the acetaminophen from the Dayquil, combined with the alcohol, creates a toxic storm within their liver. Over time, repeated occurrences could lead to inflammation, scarring, and ultimately, liver failure. This silent damage often goes unnoticed until it manifests as jaundice, abdominal pain, or other severe symptoms. The importance of understanding this connection cannot be overstated; it’s not simply a theoretical risk but a potential pathway to chronic and life-threatening conditions. The combination escalates the production of a hepatotoxic metabolite of acetaminophen, while alcohol inhibits the liver’s ability to process it effectively.

The convergence of these factors underscores a critical message: prudence is paramount. Recognizing the potential for liver damage when combining Dayquil and alcohol demands a cautious approach. Healthcare professionals consistently advise against this combination. While seemingly innocuous, the cumulative effect can inflict significant harm, emphasizing the long-term importance of adhering to dosage guidelines and avoiding alcohol consumption while taking acetaminophen-containing medications. Prioritizing liver health requires informed decision-making and a commitment to responsible medication use.

2. Increased Sedation

The quiet hum of a late-night highway. A weary traveler, battling a head cold, opts for a dose of Dayquil before embarking on the final leg of their journey. Unbeknownst to them, a celebratory drink earlier in the evening now sets a dangerous stage. Dayquil, with its carefully measured dose of antihistamines and cough suppressants, is designed to provide relief, but these very components can induce drowsiness. Alcohol, a depressant by nature, amplifies this effect. The traveler, initially feeling alert, finds their eyelids growing heavy, focus blurring. What began as a simple attempt to manage cold symptoms morphs into a perilous situation.

This scenario, repeated in countless variations, illustrates the potent synergy between Dayquil and alcohol regarding sedation. The individual components, when taken separately and responsibly, may pose minimal risk for excessive drowsiness. However, the combination dramatically elevates the likelihood and intensity of this side effect. The antihistamines in Dayquil work by blocking histamine receptors in the brain, reducing inflammation and congestion but also inducing sleepiness. Alcohol, meanwhile, depresses the central nervous system, further slowing brain activity and impairing cognitive function. Together, they create a compounded sedative effect, exceeding the sum of their individual impacts. This phenomenon is not merely a matter of feeling slightly tired; it involves a significant compromise of alertness, reaction time, and judgment, particularly hazardous in situations requiring vigilance, such as driving or operating machinery. This heightened sedation poses risks beyond accidental injuries. Imagine an elderly individual taking Dayquil for a cold, then having a glass of wine before bed. The increased sedation could lead to falls and injuries during the night, or contribute to confusion and disorientation, especially in those already vulnerable.

The confluence of Dayquil and alcohol, culminating in increased sedation, demands a heightened awareness and caution. The apparent convenience of combining these substances belies a genuine threat to safety and well-being. The key takeaway is simple: responsible medication use entails understanding the potential interactions and exercising prudence. This story, and countless others like it, underscores the importance of consulting healthcare professionals about medication interactions and choosing to err on the side of safety. The risks associated with increased sedation from this combination extend beyond mere inconvenience; they encompass potentially life-altering consequences, reinforcing the need for informed decisions and responsible behavior.

3. Impaired Judgment

The flickering neon sign of a bar cast long shadows on the rain-slicked street. Inside, a group of friends, celebrating a promotion, offered a colleague a drink. He demurred, citing a lingering cold and the Dayquil he’d taken earlier. Urged on by the celebratory atmosphere and a sense of not wanting to be a killjoy, he acquiesced, reasoning that “one drink won’t hurt.” This seemingly innocuous decision marked the beginning of a cascade of events fueled by impaired judgment. The combination of alcohol and Dayquil eroded his ability to assess risk accurately. He drove home, convinced he was sober enough, only to swerve, narrowly avoiding a collision. The immediate consequence was averted, but the underlying vulnerability exposed a significant danger. The impaired judgment stemming from combining Dayquil and alcohol doesn’t always manifest in dramatic incidents; it often operates in subtle ways, blurring lines and diminishing inhibitions, leading to choices individuals would typically avoid.

Consider the financial implications. An individual, feeling slightly euphoric and emboldened by the combined effects, might impulsively make a large, unnecessary purchase they later regret. Or consider the social realm. Impaired judgment could lead to misinterpreting social cues, resulting in inappropriate comments or actions that damage relationships. The active ingredients in Dayquil, particularly antihistamines and decongestants, can already cause cognitive clouding. Alcohol exacerbates this effect, disrupting neural pathways critical for rational decision-making. The prefrontal cortex, the brain region responsible for executive functions such as planning, impulse control, and risk assessment, becomes compromised. It’s not that the individual loses all capacity for judgment, but rather that the threshold for making sound decisions rises, and the filter through which information passes becomes distorted. This distortion can manifest as overconfidence, a reduced sense of personal responsibility, or a skewed perception of reality.

The connection between combining Dayquil and alcohol and impaired judgment is not merely a theoretical concern. It’s a real and present danger with potentially far-reaching consequences. Recognizing this risk necessitates a proactive approach. Education is paramount. Individuals must be fully informed about the potential effects of mixing these substances. Healthcare professionals should routinely counsel patients about medication interactions, particularly when prescribing or recommending over-the-counter remedies. Ultimately, safeguarding oneself and others requires a commitment to responsible decision-making. Erring on the side of caution, and abstaining from alcohol while taking Dayquil, represents a prudent choice that protects against the erosion of judgment and the potential ramifications that follow.

4. Respiratory Depression

The quiet stillness of a darkened bedroom can quickly transform into a scene of silent crisis. Respiratory depression, a potentially life-threatening condition characterized by slowed and shallow breathing, represents a critical risk when combining Dayquil and alcohol. Dayquil often contains dextromethorphan, a cough suppressant that, while effective at calming cough reflexes, can depress the central nervous system. Alcohol, a well-known depressant, amplifies this effect. Imagine an individual, seeking relief from a persistent cough, taking Dayquil before retiring for the night. Unbeknownst to them, the glass of wine consumed with dinner now interacts dangerously with the medication. As they drift off to sleep, their breathing gradually slows, the body’s natural drive to inhale diminishing. The brain, increasingly deprived of oxygen, struggles to maintain vital functions. What began as a harmless attempt to alleviate cold symptoms escalates into a precarious situation where each breath becomes shallower, each moment bringing them closer to respiratory failure. This scenario underscores the critical importance of understanding the potential for respiratory depression when combining these substances, emphasizing that this is not merely a theoretical risk but a tangible threat to well-being. The interplay between the central nervous system depressants in Dayquil and alcohol creates a synergistic effect, meaning their combined impact exceeds the sum of their individual effects. This potentiation significantly increases the risk of respiratory depression, even at dosages considered safe when taken separately.

The impact of respiratory depression extends beyond immediate physical danger. Prolonged oxygen deprivation can lead to brain damage, cardiac arrest, and other severe complications. Furthermore, certain individuals are at heightened risk. Those with pre-existing respiratory conditions, such as asthma or chronic obstructive pulmonary disease (COPD), are particularly vulnerable. Elderly individuals, whose respiratory systems may already be compromised, face increased challenges. Even seemingly healthy individuals can experience respiratory depression if they consume excessive amounts of alcohol and Dayquil simultaneously. The severity of respiratory depression can range from mild, requiring only monitoring and supportive care, to severe, necessitating mechanical ventilation to maintain adequate oxygenation. Early recognition is crucial. Signs of respiratory depression include slow, shallow breathing, confusion, dizziness, bluish discoloration of the skin (cyanosis), and unresponsiveness. Prompt medical intervention can prevent irreversible damage and potentially save lives. The awareness of respiratory depression as a key concern within the context of combining Dayquil and alcohol necessitates a proactive approach. Public health campaigns can educate individuals about the risks, healthcare providers can screen patients for predisposing factors, and pharmacists can counsel patients about medication interactions. The accessibility of naloxone, a medication that can reverse the effects of opioid-induced respiratory depression, offers a potential safety net, although it’s not directly applicable to dextromethorphan, understanding its role highlights the importance of readily available interventions.

In conclusion, the intersection of Dayquil, alcohol, and respiratory depression presents a compelling case for caution and responsible behavior. The potential for a seemingly harmless combination to trigger a life-threatening event underscores the need for informed decision-making. The challenges lie in raising awareness, particularly among those who may underestimate the risks. Overcoming these challenges requires a multi-faceted approach involving education, healthcare provider vigilance, and individual responsibility. By acknowledging and addressing the threat of respiratory depression, society can mitigate the potential harms associated with combining Dayquil and alcohol, prioritizing safety and protecting vulnerable individuals from avoidable tragedy. The issue is not merely academic; it’s a matter of life and breath, emphasizing the urgency of widespread understanding and preventative measures.

5. Medication Interactions

The intersection of pharmaceuticals and alcohol often presents a silent, unseen minefield, fraught with the potential for dangerous interactions. Consider the common cold, a seasonal nuisance many combat with over-the-counter remedies like Dayquil. Dayquil, a blend of various active ingredients, aims to alleviate congestion, suppress coughs, and reduce fever. Individually, these components are generally safe when used as directed. However, the introduction of alcohol into this equation can drastically alter the landscape, creating a scenario where the whole becomes significantly more dangerous than the sum of its parts. The liver, tasked with processing both the medications and the alcohol, can become overwhelmed, leading to a cascade of adverse effects. Acetaminophen, a frequent constituent of Dayquil, carries a known risk of liver damage, a risk amplified when combined with alcohol. This is not merely a theoretical concern; countless cases exist where individuals, unknowingly exceeding the liver’s capacity, have suffered severe hepatic injury, sometimes requiring hospitalization or even liver transplantation. This illustrates the critical importance of understanding medication interactions, particularly when mixing seemingly innocuous over-the-counter drugs with alcohol.

Beyond liver toxicity, other interactions can manifest in equally concerning ways. Dayquil often contains antihistamines, designed to dry up nasal passages and reduce sneezing. These antihistamines also possess sedative properties, making one feel drowsy. Alcohol, itself a depressant, intensifies this sedation. The result can be a profound impairment of cognitive function and reaction time, rendering activities like driving or operating machinery extremely hazardous. The risk extends beyond immediate physical danger. Impaired judgment, a consequence of these interactions, can lead to poor decision-making in various aspects of life, from financial choices to social interactions. Further complicating matters, some individuals may be taking prescription medications that interact negatively with both Dayquil and alcohol. For instance, those taking antidepressants or anti-anxiety medications may experience a dangerous potentiation of sedative effects, potentially leading to respiratory depression. This intricate web of interactions highlights the necessity for clear communication between patients, physicians, and pharmacists.

Navigating the potential pitfalls of medication interactions demands a proactive approach. Individuals should meticulously read medication labels, paying close attention to warnings regarding alcohol consumption. Healthcare providers should routinely inquire about alcohol use when prescribing medications, and pharmacists should serve as a crucial point of contact for clarifying potential interactions. Public awareness campaigns can play a vital role in educating the public about the risks of mixing medications and alcohol. Ultimately, responsible self-care requires a commitment to informed decision-making. Abstaining from alcohol while taking Dayquil, or any medication with known interactions, represents a prudent choice that safeguards one’s health and well-being. The seemingly simple act of reading a label or consulting a healthcare professional can prevent a cascade of adverse events, underscoring the profound significance of understanding and respecting the potential for medication interactions. The key takeaway is that ignorance is not bliss; in this realm, it can be downright dangerous.

6. Overdose Risk

The specter of overdose looms large when Dayquil and alcohol intertwine. Each substance, in isolation, carries its own set of potential dangers; combined, they create a synergistic toxicity, a dangerous amplification of adverse effects. The story often unfolds subtly, innocently enough. A person, battling the flu, seeks solace in Dayquil’s symptom-relieving properties. Perhaps later, a social occasion arises, and a drink seems harmless, a fleeting moment of normalcy amidst illness. Yet, this seemingly innocuous combination initiates a perilous cascade. The active ingredients in Dayquil, particularly acetaminophen and dextromethorphan, become more potent in the presence of alcohol. Acetaminophen, intended to ease aches and fever, poses a significant threat to the liver, a threat exponentially magnified by alcohol’s presence. The liver, already burdened by metabolizing both substances, struggles to keep pace, leading to inflammation, cellular damage, and potentially, liver failure. Dextromethorphan, a cough suppressant, can induce central nervous system depression, a risk exacerbated by alcohol’s depressant effects, leading to slowed breathing, loss of consciousness, and in extreme cases, death. The understanding of this overdose risk is not merely academic; its a matter of life and death, a crucial piece of knowledge that can prevent tragedy. The insidious nature of this risk lies in its gradual onset. Early symptoms may be subtle: nausea, abdominal pain, drowsiness. These symptoms can easily be dismissed as flu-related, delaying critical medical intervention. As the liver and central nervous system succumb to the toxic assault, the situation spirals rapidly, often culminating in irreversible organ damage or fatal respiratory failure.

Consider the hypothetical scenario: an individual takes the maximum recommended dose of Dayquil while simultaneously consuming several alcoholic beverages over the course of an evening. This person, unaware of the dangers, feels progressively worse but attributes their discomfort to the flu. By the time they seek medical attention, significant liver damage has already occurred, necessitating intensive care and potentially a liver transplant. This scenario, unfortunately, is not merely hypothetical; its a reality played out in emergency rooms across the nation. The tragic element is that it is often preventable through simple education and awareness. The risk is heightened in individuals with pre-existing liver conditions, those who chronically abuse alcohol, and those who may be unknowingly taking other medications that interact with both Dayquil and alcohol. Further complicating the matter is the potential for misdiagnosis. The symptoms of Dayquil and alcohol overdose can mimic other medical conditions, leading to delays in treatment and further exacerbating the damage. The practical significance of understanding this overdose risk lies in its ability to empower individuals to make informed choices. Knowledge is the first line of defense. Awareness of the potential dangers can prompt individuals to avoid the combination altogether, to carefully monitor their intake, and to seek prompt medical attention if symptoms arise.

The challenge in addressing the overdose risk associated with combining Dayquil and alcohol lies in overcoming public misconceptions and fostering responsible behavior. Many individuals underestimate the potency of over-the-counter medications, viewing them as harmless remedies rather than potentially dangerous substances. The societal acceptance of alcohol consumption further complicates matters, blurring the lines between responsible use and harmful excess. Ultimately, mitigating the overdose risk requires a multi-faceted approach: comprehensive public health campaigns, clear and concise labeling on medication packaging, readily accessible information for healthcare providers and pharmacists, and a collective commitment to promoting responsible medication use and alcohol consumption. The broader theme at stake is personal responsibility and informed decision-making. Individuals must recognize that their choices have consequences and that seemingly innocuous combinations can carry significant risks. The specter of overdose serves as a stark reminder of the importance of respecting the power of medications and the potential dangers of alcohol, urging us to prioritize our health and well-being above fleeting moments of relief or social pressure. The knowledge of overdose risks when it comes to Dayquil and Alcohol can save lives.

Frequently Asked Questions

The subject of mixing Dayquil and alcohol raises many concerns, each rooted in the potential for adverse health effects. These frequently asked questions aim to provide clarity and address common misconceptions surrounding this potentially dangerous combination. A story of a young athlete, sidelined by a cold, illustrates the need to understanding these interactions. Despite feeling unwell, he planned to attend a team celebration. Unaware of the risks, he took Dayquil to alleviate symptoms and then consumed alcohol at the party. The consequences were severe: a night in the emergency room due to acute liver distress. This cautionary tale underscores the importance of the following information.

Question 1: Is it safe to consume even a small amount of alcohol while taking Dayquil?

The consensus among medical professionals is a resounding no. Even a small quantity of alcohol can exacerbate the side effects of Dayquil, particularly drowsiness and impaired coordination. The risk of liver damage, especially concerning acetaminophen-containing Dayquil formulations, also increases even with minimal alcohol consumption. The severity of the interaction can vary based on individual factors, but erring on the side of caution is always advised.

Question 2: What are the primary risks associated with combining Dayquil and alcohol?

The primary risks revolve around liver damage, increased sedation, impaired judgment, and potential respiratory depression. The liver, responsible for metabolizing both substances, can become overwhelmed, leading to hepatic injury. The combination also intensifies the sedative effects of Dayquil, increasing the risk of accidents and falls. Impaired judgment can lead to risky behaviors, and in extreme cases, respiratory depression can become life-threatening.

Question 3: If I’ve already taken Dayquil, how long should I wait before consuming alcohol?

A conservative approach dictates waiting until the Dayquil has completely cleared from the system. This timeframe typically extends beyond 24 hours, as the active ingredients have varying half-lives. Consulting a healthcare professional or pharmacist is recommended to obtain a more precise estimate based on the specific Dayquil formulation and individual health factors.

Question 4: Are certain Dayquil formulations riskier to combine with alcohol than others?

Dayquil formulations containing acetaminophen pose the greatest risk when combined with alcohol due to the potential for liver damage. However, all Dayquil formulations, regardless of their specific ingredients, can interact negatively with alcohol by increasing sedation and impairing cognitive function. Vigilance is paramount regardless of the specific formulation.

Question 5: Can the effects of combining Dayquil and alcohol be mitigated by drinking plenty of water or eating food?

While staying hydrated and consuming food can help to alleviate some of the general side effects of alcohol, these measures do not mitigate the fundamental risks associated with combining Dayquil and alcohol. The liver damage and central nervous system depression remain significant concerns, regardless of hydration or food intake. These strategies offer limited protection against the core dangers.

Question 6: What should an individual do if they have already consumed Dayquil and alcohol?

If an individual has consumed Dayquil and alcohol and is experiencing adverse symptoms such as severe drowsiness, abdominal pain, difficulty breathing, or confusion, immediate medical attention is warranted. These symptoms could indicate a serious medical emergency requiring prompt intervention. Do not hesitate to seek professional help.

The key takeaway from these frequently asked questions is the consistent message of caution. Combining Dayquil and alcohol carries significant risks that outweigh any perceived benefits. Prioritizing health and well-being necessitates making informed choices and avoiding this potentially dangerous combination.

Moving forward, the article will delve into alternative strategies for managing cold and flu symptoms that do not involve the use of Dayquil or other medications known to interact negatively with alcohol.

Navigating Cold Season

Winter evenings, often alight with festive gatherings, pose a unique challenge for those battling seasonal ailments. The temptation to alleviate symptoms with medication while simultaneously participating in social events where alcohol flows freely can lead to dangerous decisions. The following offers prudent guidance for navigating this treacherous landscape.

Tip 1: Prioritize Rest and Hydration: The human body possesses remarkable healing capabilities. Before reaching for medication, explore the restorative power of ample rest and diligent hydration. A warm broth, a quiet evening, and a commitment to sleep can often mitigate symptoms without the need for pharmaceutical intervention. Consider the lumberjack, felled not by a tree but by ignoring the subtle aches of his body, pushing onward until illness brought him crashing down. He would have fared better by taking a break.

Tip 2: Scrutinize Medication Labels with Diligence: Pharmaceutical companies painstakingly craft warnings and contraindications. Treat these labels as vital intelligence, not mere fine print. Before ingesting any medication, meticulously review the potential interactions with alcohol. If uncertainty persists, seek clarification from a pharmacist or medical professional. The seasoned sailor studies the nautical chart before setting sail, knowing hidden reefs await the unwary; medication labels deserve similar scrutiny.

Tip 3: Advocate for Abstinence: Social pressure can be formidable, particularly during celebrations. However, assertiveness in protecting one’s health is paramount. Politely decline alcoholic beverages, explaining the use of medication. Most individuals will respect a commitment to personal well-being. Remember the weary traveler who, yielding to peer pressure, indulged in a “harmless” drink only to find himself battling debilitating drowsiness on a dangerous road. His momentary social discomfort paled in comparison to the potential consequences.

Tip 4: Explore Non-Pharmacological Alternatives: Nature offers a bounty of remedies for common cold symptoms. Herbal teas, honey lozenges, steam inhalation, and saline nasal rinses can provide relief without the risks associated with medication interactions. The ancient healer relied on nature’s pharmacy, understanding the potent effects of herbs and natural therapies; modern individuals should not dismiss these time-tested remedies.

Tip 5: Consult a Healthcare Professional: For persistent or severe symptoms, seek guidance from a physician or qualified healthcare provider. These professionals can accurately diagnose the underlying cause of the illness and recommend appropriate treatment strategies, taking into account individual health factors and potential medication interactions. The seasoned explorer relies on the expertise of a local guide to navigate unfamiliar terrain; similarly, a healthcare professional can provide invaluable guidance in navigating illness.

Tip 6: Time Your Medication Wisely: If medication is unavoidable, strategically time its administration to minimize overlap with potential alcohol consumption. For example, administer Dayquil during daylight hours and abstain from alcohol until the medication has substantially cleared from the system, typically exceeding 24 hours. The chess master plans several moves ahead, anticipating potential threats and strategizing accordingly; timing medication requires similar foresight.

Tip 7: Be Vigilant for Adverse Reactions: Even with careful planning, unexpected reactions can occur. Be acutely aware of any unusual symptoms, such as dizziness, confusion, abdominal pain, or difficulty breathing. Seek immediate medical attention if these symptoms arise. The seasoned watchman remains ever vigilant, scanning the horizon for signs of danger; similar vigilance is warranted when combining medications with other substances.

Tip 8: Prioritize Transparency with Healthcare Providers: When discussing treatment options with doctors and pharmacists, explicitly mention any planned or recent alcohol consumption. This transparency allows healthcare professionals to provide tailored advice and avoid potentially harmful medication combinations. The successful diplomat thrives on open communication, fostering trust and understanding; similar transparency with healthcare providers is crucial for informed decision-making.

These tips underscore a fundamental principle: proactive, informed decision-making is the cornerstone of responsible self-care. By prioritizing rest, scrutinizing medication labels, advocating for abstinence, exploring natural alternatives, consulting healthcare professionals, timing medication strategically, remaining vigilant for adverse reactions, and prioritizing transparency, individuals can navigate cold season safely and confidently.

The forthcoming conclusion will synthesize these key insights, reinforcing the paramount importance of informed choices in protecting one’s health during periods of illness and celebration.

A Silent Toast to Caution

The exploration of whether one can safely combine Dayquil and alcohol has illuminated a precarious intersection of medication and societal habit. A confluence of liver strain, intensified sedation, impaired judgment, and even respiratory distress can arise. The narrative reveals how a seemingly innocuous decision a dose of over-the-counter cold medicine followed by a celebratory drink can set in motion a cascade of adverse health consequences. From the risks of liver damage to the insidious clouding of cognitive function, the consistent message has been one of caution.

Consider the memory of a seasoned physician, witnessing the aftermath of such a combination. The regret etched on the patient’s face served as a constant reminder: a moment of uninformed choice can leave a lasting mark. The knowledge presented is not merely theoretical; it is a call to awareness. Understanding the potential ramifications allows for a proactive stance. May this serve as a guiding light, illuminating the path toward informed decisions, ensuring that future toasts are raised in the spirit of genuine celebration, free from the shadow of avoidable harm.

Leave a Comment

close
close